RIOX2 and COVID-19: This analysis showed that the down-regulated genes in the mdig KO cells were over-presented in the gene sets induced by SARS-CoV-2 in intestinal organoids (GSE149312), cardiomyocytes (GSE150392), A549 cells (GSE147507), and bronchoalveolar lavage fluid (BALF) of COVID-19 patients (Fig. 1B), suggesting that mdig enhances expression of genes involved in either SARS-CoV-2 infection or the pathogenesis of COVID-19.