In sharp contrast, the analysis of Th1-dedicated cytokines in the sera derived from tumor antigen-expressing RIP1-Tag2 mice 5 days after TBI exhibited a significant (~30%) increase in TNF and non-statistically significant but apparent tendencies towards enhanced IFN-γ, IL-12, and CXCL10 protein release compared to RIP1-Tag2 mice without TBI, indicating promotion of a Tag2-specific antitumoral Th1 immune response (Figure 5E). The gene discussed is TNF; the disease is neoplasm.