SNAI1 and breast neoplasm: Afterwards, we proceeded to analyze the effect of Snail1 endothelial depletion in breast tumor development mating our VE-Cadh-CreERT2, Snail1Flox/Snail1del (or Snail1Flox/Snail1WT) animals with mice expressing PyMT under the control of MMTV promoter (MMTV-PyMT mice).