Based on these results, we speculate that this type of multiayed regulation of METTL3 in downstream proteins and upstream signaling pathways might effectively mediate PCa progression; however, whether the Hedgehog, Akt, and Wnt signaling pathways are involved in METTL3-mediated ARHGDIA expression deserves a separate study. The gene discussed is AKT1; the disease is posterior cortical atrophy.