METTL3 and posterior cortical atrophy: To further confirm the role of METTL3 in mediating the PCa metastasis, we transfected the METTL3 expression plasmid into those PCs cells with knockout of METTL3, and we found that METTL3 overexpression effectively rescue the METTL3 deficiency-induced suppressed migratory and invasive capacities of PCa cells (Figure S4).