ERBB2 and breast cancer: NAC for operable breast cancer can eliminate axillary nodal metastasis to avoid axillary dissection, and several prediction models on this have been developed.12, 27-29 One prospective and another retrospective study found that N-pCR is highly correlated with B-pCR, and nodal positivity rates were <2% after NAC in HER2(+) and triple-negative breast cancer.