For instance, downregulation of EGFR, Forkhead box C1 (FOXC1) and Forkhead box Q1 (FOXQ1) by miR-133 was thought to mediate reduced cell proliferation, migration and invasion of prostate cancer 14, pituitary adenoma 22 and lung cancer 23, respectively. The gene discussed is FOXC1; the disease is prostate cancer.