To explore the role of TIP60 in liver cancer, Wang et al. used ChIP and FISH assays to indicate that TIP60 was recruited by circRHOT1 to combine with the NR2F6 promoter, and next actively recruited other components of NuA4 complex to finally enhance target gene NR2F6 expressions, resulting in suppressing HCC development and progression. The gene discussed is NR2F6; the disease is hepatocellular carcinoma.