SOX4 and non-small cell lung carcinoma: In this study, circ-SOX4 upregulation was illustrated to enhance c-MYC expression via triggering the Wnt/β-catenin axis in NSCLC, while up-regulated c-MYC enabled circ-SOX4 to accelerate transcription by binding to circ-SOX4 promoter, thus forming a positive feedback 81.