Furthermore, a novel epigenetic pathway was discovered that FECR1 could bind to the parental gene FLI1 promoter in cis and acts as a protein recruiter for TET1 demethylase which demethylated the promoter CpG islands, thereby activating transcription of the oncogene FLI1 to promote tumor metastasis 46 (Figure 2B). This evidence concerns the gene FLI1 and neoplasm.