CD58 and central nervous system cancer: Consistent with the high expression in GBM subtype, previous reports suggested that CCDC109B 27, CD58 28, CLIC1 29, EFEMP2 30, EMP3 31-33, LAMC1 34, LGALS1 35, PDLIM1 36 and TNFRSF1A 37, 38 were all bad prognostic factors in glioma, as were summarized in Fig. 2A. However, the prognostic effects of CDHR1 in glioma were never reported and searching with the keywords of “CDHR1 in glioma” had failed to retrieve any related publication in PubMed.