The fold changes of CCDC109B, CD58, CDHR1, CLIC1, EFEMP2, EMP3, LAMC1, LGALS1, PDLIM1 and TNFRSF1A in GBM were further illustrated in Fig. 2A. Compared with LGG, CCDC109B, CD58, CLIC1, EFEMP2, EMP3, LAMC1, LGALS1, PDLIM1 and TNFRSF1A were all highly expressed in GBM. Here, CD58 is linked to glioblastoma.