The fold changes of CCDC109B, CD58, CDHR1, CLIC1, EFEMP2, EMP3, LAMC1, LGALS1, PDLIM1 and TNFRSF1A in GBM were further illustrated in Fig. 2A. Compared with LGG, CCDC109B, CD58, CLIC1, EFEMP2, EMP3, LAMC1, LGALS1, PDLIM1 and TNFRSF1A were all highly expressed in GBM. The gene discussed is LAMC1; the disease is glioblastoma.