Among the differentially expressed genes (DEGs), especially within the CST family, we had found significant upregulation of CST2 mRNA expression in CRC tissues, with high CST2 expression being closely associated with shorter overall survival (OS) and disease-free survival (DFS) in patients with CRC, suggesting that the CST2 gene may play an important role in tumor development. Here, CST2 is linked to colorectal carcinoma.