The tumor suppressor PAX1 is aberrantly methylated in various human malignancies, such as oral cancer 18, esophageal cancer 19, ovarian cancer 20 etc. PAX1 inhibits cancer cell growth by forming complexes with SETIB and WDR5 to activate phosphatase that inhibit the oncogenic MAPK and SRC pathways 21. This evidence concerns the gene PAX1 and esophageal cancer.