In line with this, we knocked down ADNP in T24 and BIU87 BC cells and found the expression of TGFβ, TGF-βRI and p-Smad2/3 were decreased, in contrast, overexpression of ADNP in 5637 and TCCSUP BC cells showed opposite results, indicating that ADNP promoted cell migration and EMT, thereby inducing cisplatin resistance, which may be related to TGF-β/Smad signaling pathway. This evidence concerns the gene ADNP and breast cancer.