Indeed, TP53 mutation was present in 76.3% of the cohort, but RB1 was only mutated in 56.2%, however, when only SNVs/indels were taken into account, our result was only slightly lower than the 64% previously reported for Chinese SCLC patients in blood, although both were lower than the incidence of SNVs/indels based on tissue-testing 15, 22. Here, RB1 is linked to small cell lung carcinoma.