For example, one study found evidence of a close correlation between the serum level of IL-18 at day 7 poststroke and depression scores at 2 weeks after the initial onset of AIS [19]; another study reported that IL-1β and TNF-α, as well as their polymorphisms, were involved in the pathogenic process of PSD [20]. This evidence concerns the gene IL18 and androgen insensitivity syndrome.