Tumor-associated macrophages (TAMs) represent the largest population of infiltrating inflammatory cells in malignant tumors, altering the tumor microenvironment to contribute to the regulatory process of tumor progression through immunosuppression, stroma formation, invasion, angiogenesis, metastases, and secretion of proangiogenic factors such as vascular endothelial growth factor (VEGF). The gene discussed is VEGFA; the disease is neoplasm.