TGF-β also enhances tumor invasiveness and angiogenesis by promoting the production and secretion of matrix metalloproteases proteinase-2 (MMP-2) and matrix metalloproteinase-2 (MMP-9) and downregulating the expression of tissue inhibitors of metalloproteases (TIMP) [8, 16–18]. The gene discussed is MMP2; the disease is neoplasm.