CASP1 and Ureteral obstruction: For this study, we used 6-month-old unilateral ureteral obstruction (UUO) rats to model the process of chronic obstructive nephropathy to observe the effect of HJHF on contralateral kidney injury and then explored the mechanisms of aldosterone-induced pyroptosis on the basis of the NLRP3/caspase-1/IL-1β pathway.