It has also been shown that extracts from the fruit had cytotoxic effects against CCRF-CEM leukemia cells and MDA-MB-231-pcDNA3 breast cancer cells as well as their drug-resistant variants, CEM/ADR5000 and MDA-MD-231-BCRP, with IC50 values of 10.27, 20.47, 17.16, and 15.75 μg/mL, respectively [35]. The gene discussed is ABCG2; the disease is breast carcinoma.