Several PTs were involved in PI3K-Akt signaling (e.g., PIK3CA, PRKAA2, RELA, and TP53), the breast cancer pathway (e.g., AKT1, MTOR, NOTCH1, PIK3CA, and TP53), and the TNF signaling pathway (e.g., MMP9, NFKB1, PIK3CA, PTGS2, and RELA) (Supplementary Table 5). Here, PTGS2 is linked to breast cancer.