Pathway enrichment by KEGG of the PTs (Supplementary Table 3) showed the regulation of ∼106 pathways, including the PI3K-Akt, breast cancer, and TNF signaling pathways (Supplementary Table 4), three main pathways that are regulated by tangeretin in metastasis signaling, based on the literature study. The gene discussed is PIK3CA; the disease is breast carcinoma.