Meanwhile,insulin resistance-related signaling pathways include c-Jun amino terminal kinase (JNK) signaling pathway, NF-κB signaling pathway, SOCS-3 signaling pathway, INOS-NO signaling pathway, PKC signaling pathway, and other pathways related to PTP-1 B and glycogen synthase 3 [39–43]. Here, MAPK8 is linked to Insulin resistance.