Further analysis showed that higher CD8 T cells were associated with longer HCC development time (HR = 1.96, 95% CI: 1.11–3.40, p=0.02, Figure 8(b)), which may indicate that the signature may affect HCC development of early-stage liver cirrhosis patients by the regulation of the infiltration of CD8 T cells. The gene discussed is CD8A; the disease is cirrhosis of liver.