For example, Zhou et al. have found that vorinostat can lead to HCC cell morphology changes, growth inhibition, cell cycle blockage, and apoptosis in vitro and suppressed the growth of subcutaneous HCC xenograft tumours in vivo via upregulation of p21Waf1/Cip1 and p19INK4d [40]. The gene discussed is CDKN2D; the disease is hepatocellular carcinoma.