It is proved that alterations in homeostasis of glucose play an important role in the development of tumors, loss of fructose-1, 6-bisphosphatase (FBP1), a rate-limiting enzyme in gluconeogenesis, was found to be oncogenic in various cancer cells including HCC and colon cancer cells [42], suggesting that modulation of gluconeogenesis also plays an equal role in tumorigenesis. Here, FBP1 is linked to hepatocellular carcinoma.