Higher proportions of resting mast cells, neutrophils, CD8 T cells, and total T cells were found to be enriched in HCC patients with low risk score, while only activated mast cells was found to be higher at patients with high risk score, which indicates the immune-enriched phenotype in low-risk patients and immune-depleted phenotype in high-risk patients. Here, CD8A is linked to hepatocellular carcinoma.