In summary, our data demonstrated that the elevated levels of CXCL9, CXCL10, IL-6, and IL-10 and the moderate and strong correlations displayed by CXCL9, CXCL10, and IL-10, together with the negative correlations of CXCL8 and CCL2, may be related to the suppression of the Th1 profile on D0, which contributes synergistically to an immune system imbalance in B-ALL. Here, IL6 is linked to precursor B-cell acute lymphoblastic leukemia.