There is incomplete information about the impact of plasmatic SHBG and development of cardiometabolic disease in youth, but the evidence showed a correlation between circulating SHBG, hypogonadism, insulin resistance, cardiac metabolism, and dyslipidemia, which are related with low circulating SHBG levels as a result of altered SHBG hepatic production. Here, SHBG is linked to hypogonadism.