HMGB1 and adrenal cortex carcinoma: Figure 1(b) displayed the PPI network suggesting that TP53, HMGB1, CDKN2A, and MAPK1 were the hub genes. The association among these genes was exhibited in Figure 1(c). 11 ferroptosis-associated genes were finally reserved after lasso regression analysis (Figure 1(d)). In addition, through further multivariate Cox regression analysis to eliminate the possible interaction among the candidate genes, six genes (SLC7A11, TP53, HELLS, ACSL4, PCBP2, and HMGB1) were screened out (p < 0.05), suggesting their strong correlations to the OS of ACC patients (Figure 1(f)).