DETFs such as basic helix-loop-helix family member E40 (BHLHE40), E2F transcription factor 1 (E2F1), early growth response 2 (EGR2), FOS like 1, AP-1 transcription factor subunit (FOSL1), forkhead box M1 (FOXM1), kruppel like factor 5 (KLF5), LEF1, LMNB1, peroxisome proliferator activated receptor gamma (PPARG), PR/SET domain 1 (PRDM1), transcription factor AP-2 alpha (TFAP2A), tumor protein P63 (TP63), and VDR might regulate the DEIRGs in PAAD. The gene discussed is LEF1; the disease is pancreatic adenocarcinoma.