E2F1-mediated overexpression of long non-coding (lnc)RNA-pancreatic cancer associated transcript 1 (PLACT1) promotes the growth of PAAD by continuously activating the NF-κB pathway and forming a positive feedback loop with IκBα in PC (Ren et al., 2020). The gene discussed is NFKBIA; the disease is pancreatic adenocarcinoma.