LEPN observed in this EWAS is involved in angiogenesis, PTGS1 from isocyanate-asthma research (Yucesoy et al., 2016) is involved in angiogenesis regulation (RefSeq, 2014), and SALL1 and PDZRN3 observed in our GWAS on isocyanate biomarkers (Taylor et al., 2020) are also involved in angiogenesis and vascular morphogenesis, respectively (Yamamoto et al., 2010; Sewduth et al., 2014). The gene discussed is PTGS1; the disease is asthma.