In colorectal cancer and LIHC, SMYD3 can activate multiple signal pathways by regulating transcription, and promote, among other malignant cell phenotypes, tumor cell proliferation, invasion, and epithelial to mesenchymal cell transformation (Hamamoto et al., 2004; Sarris et al., 2016; Chen et al., 2019). Here, SMYD3 is linked to neoplasm.