TP53 and cancer: Along with other members of the sirtuin family, SIRT6 and SIRT7 also regulate P53, E2F1, PARP, and SMAD4, as well as the functional proteins or miRNAs in cancers with opposing phenotypes (Mao et al., 2011; Sebastián et al., 2012; Kim et al., 2013; Malik et al., 2015; Wu et al., 2015; Zhang S. et al., 2015; Elhanati et al., 2016; Wang et al., 2017).