IFITM5 and ptosis: For example, OI type V caused by the [Interferon-induced transmembrane protein 5(IFITM5); MIM 614757] gene mutation will be accompanied by the formation of huge callus, calcification of interosseous membrane, and subluxation of radial capitulum (Semler et al., 2012); OI type XI caused by mutations of [FK506 binding protein 10 (FKBP10); MIM 607063] is characterized by congenital joint contractures (Zhou et al., 2014); patients with the P4HB (Prolyl 4-hydroxylase; MIM: 176790) mutation may present with craniosynostosis, exophthalmos, blepharoptosis, and even hydrocephalus (Rauch et al., 2015).