Secondly, we found that FSTL3 expression has an observably positive association with ImmuneScore (R = 0.37, P < 0.001, Figure 9B), StromalScore (R = 0.54, P < 0.001, Figure 9C), but negative association with TumorPurity (R = −0.49, P < 0.001, Figure 9D) in CRC, which demonstrate that FSTL3 has a major influence on ECM remodeling. The gene discussed is FSTL3; the disease is colorectal carcinoma.