Additionally, in a recent study reported by Shi et al., a vaccine with exosomes derived from IFN-γ-modified RM-1 prostate cancer cells under a vaccination regimen of 4 injections (on days 0, 4, 8, and 12), decreased the number of Tregs and reduced the tumor metastatic rate in C57BL male mice with lung metastasis (126). Here, IFNG is linked to neoplasm.