Adoptive transfer of CD8+ cytotoxic T lymphocytes (CTL) obtained from OVA-specific ovalbumin transgenic mice, which only have TCRs specific to a chicken protein, to Rag-/- mice caused a smaller infarct volume at 7 days and 14 days after stroke and a reduced number of infiltrated CTLs in the parenchyma (73). The gene discussed is CD8A; the disease is stroke disorder.