RTL551, which contains the α1 and β1 domains of the I-A(b) class II molecule covalently linked to the encephalitogenic MOG-35-55 peptide, reversed symptoms in experimental autoimmune encephalomyelitis mice and reduced IL-17 and TNF-α secretion from MOG-33-35 reactive CD4+ T cells (142, 143). The gene discussed is MOG; the disease is experimental autoimmune encephalomyelitis.