A weak association between an IFN signature and the cutaneous, hematological or biological domains of the EULAR Sjögren ́s syndrome disease activity index (ESSDAI) has been reported, whereas Bodewes et al. only found an association with the biological domain (includes cryoglobulinemia, low complement, hypergammaglobulinemia or clonal component) (9, 10, 34). This evidence concerns the gene IFNA1 and Sjogren syndrome.