S1PR1 and Familial prostate cancer: For instance, a variety of GPCRs and their ligands are involved in tumor angiogenesis, such as angiotensin (Ang) II type I receptor/AngII in breast cancer, sphingosine-1-phosphate receptor 1 (S1PR1)/sphingosine-1-phosphate (S1P) in lymphangiogenesis, CXCR4/CXCL12 in prostate cancer, and CXCR7/CXCL12 in human hepatocellular carcinoma cells (20).