EGR1 and hepatocellular carcinoma: For instance, in human hepatocellular carcinoma cell lines (HCCLM3 and HepG2), overexpression of GRK2 inhibits IGF1R signaling activation, the activation of PI3K/AKT and MEK/ERK pathways, and the expression of early growth response protein 1 (EGR1), which results in the suppression of proliferation and migration of cells.