GRK2 can also repress the serum-, insulin-like growth factor 1 (IGF1)-, angiotensin (Ang)II-, tumor necrosis factor (TNF) α- or PDGF-induced proliferation and migration of thyroid cancer cell lines (35), human hepatocellular carcinoma cells (32, 36) and smooth muscle cells (27, 28), respectively. This evidence concerns the gene GRK2 and hepatocellular carcinoma.