GRK2 can also repress the serum-, insulin-like growth factor 1 (IGF1)-, angiotensin (Ang)II-, tumor necrosis factor (TNF) α- or PDGF-induced proliferation and migration of thyroid cancer cell lines (35), human hepatocellular carcinoma cells (32, 36) and smooth muscle cells (27, 28), respectively. The gene discussed is IGF1; the disease is hepatocellular carcinoma.