From the 45 genes lower in COVID-19 patients, there is an enrichment in major histocompatibility complex (MHC) class II proteins through genes HLA-DOA, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, and HLA-DPB1. The gene discussed is HLA-DQB1; the disease is COVID-19.