Moreover, the Nlrc3−/− mice also showed a higher viral load in the serum, spleen, and kidney than WT mice, and Nlrc3−/− mice developed hematological disorder and significant pathological changes in multiple organs, and thus establishing HTNV infection of Nlrc3−/− mice as a new model for studying HFRS. Here, NLRC3 is linked to hemorrhagic fever with renal syndrome.