Moreover, absence of Kmt2d affects negatively the expression of major B-cell tumor suppressors such as Tnfaip3, Socs3, Tnfrsf14, Asxl1 or Arid1a. In conclusion, lack of Kmt2d leads to an aberrant repression of key genes normally required for GC exit, favoring an abnormal GC B cell outgrowth and failure to differentiate leading eventually to lymphoma development. This evidence concerns the gene KMT2D and lymphoma.