Interestingly, the generation of Kmt2dflox/floxCd19-Cre crossed with a strain overexpressing AID led to the development of aggressive lymphomas resembling DLBCLs and confirms that, independently from BCL2 expression, genetic instability linked to AID overexpression cooperates with Kmt2d loss to promote lymphomagenesis. Here, AICDA is linked to lymphoma.