Integrative genomic analyses from human samples carrying KMT2D mutations and Kmt2d-mouse FLs showed that genes differentially expressed in Kmt2d-mutated lymphomas were mostly repressed and affected a set of genes involved in terminal differentiation programs and GC exit, such as CD40 and BCR signaling, regulation of apoptosis, control of cell migration and proliferation. This evidence concerns the gene CD40 and lymphoma.