Ezh2Y641F Bcl2+ chimeric mice led to early lymphoma development in 70% of mice at 111 days (vs 20% in mice overexpressing Ezh2WTBcl2+ and none in the Bcl2 control at that stage), characterized by enlarged spleen and liver and resembling morphologically to DLBCL with centroblastic morphology (73, 74). Here, BCL2 is linked to diffuse large B-cell lymphoma.