Moreover, although GC-specific deletion was insufficient to initiate malignant transformation, Kmt2dko-VavP-Bcl2 double-mutant mice developed B-cell lymphoproliferative disorders with an incidence of 78% (44% for VavP-Bcl2 alone), with tumors expressing BCL6 and PAX5 consistent with a GC origin and recapitulating a spectrum of histopathological features ranging from early FL to DLBCL (40% early FL, 31% FL and 27% DLBCL) (70). This evidence concerns the gene PAX5 and diffuse large B-cell lymphoma.