BCL2 and lymphoma: To recapitulate SESTRIN1 deficiency in vivo, in combination with BCL2 overexpression, Oricchio and colleagues retrovirally transduced VavP-Bcl2 HSPCs with shRNAs targeting Sestrin1. Sestrin1 deficiency led to an acceleration of the Bcl2-mediated lymphoma, establishing his tumor suppressive role in B cells.