Among the downregulated pathways in extracellular inhibitor-treated group, IL-17 pathway (proteins S100A8/A9), African trypanosomiasis, malaria (haemoglobin subunit beta 1), arginine and proline metabolism (creatinine kinase M-type) and glycosaminoglycan biosynthesis pathways (Xylosyltransferase 2) were in top 5 pathways compared to control (Table 1C). This evidence concerns the gene S100A8 and malaria.