Moreover, pathways related to cardiac function (hypertrophic and dilated cardiomyopathy, cardiac muscle function), glycolysis, metabolic pathways (glycine, serine, threonine, thiamine, pyruvate, propanoate metabolism) and glucagon signalling were decreased in extracellular inhibitor-treated mice compared to intracellular CTSD inhibitor- treated mice (Table 1D). This evidence concerns the gene CTSD and dilated cardiomyopathy.