CD19 and acute lymphoblastic leukemia: Three CD19-directed CAR-T (CART19) cell products, tisagenlecleucel, axicabtagene ciloleucel, and brexucabtagene autoleucel have been approved by the U.S. FDA for the treatment of children with acute lymphoblastic leukemia (ALL) and adults with advanced large B-cell lymphoma (LBL) and mantle cell lymphoma (MCL), respectively.