Yet it may allow to validate – although most likely not at this point in a routine fashion – whether MHC-peptide specific clonal TCRs are present within cancer or tissue lesions by modeling T-cell MHC epitope specificity (316) using yeast-display libraries of MHC-peptide complexes tested for TCR recognition as shown for TIL in colorectal adenocarcinoma (317). The gene discussed is HLA-C; the disease is colorectal adenocarcinoma.