infection of dendritic cells results in downregulation of costimulatory markers (i.e., CD80 and CD86) and decreased production of proinflammatory cytokines while infection with rough mutants, such as RB51, results in the opposite effect (Zwerdling et al., 2008; Surendran et al., 2012; Avila-Calderón et al., 2020). Here, CD80 is linked to infection.