The reported involvement of porins in the virulence phenotype and biocide resistance of some rapidly growing mycobacteria, combined with the finding of deletions and rearrangements in the porin genes of serially collected Mabs and Mmas isolates from CF patients and genetic polymorphisms affecting the porin locus of MABSC isolates globally, led us to investigate the potential roles played by Msp-type porins in the adaptation of MABSC to the host and to antibiotic and disinfectant exposure. The gene discussed is VDAC1; the disease is cystic fibrosis.