IRF3 and COVID-19: It has been found that about 3.5% of COVID-19 patients had known autosomal-recessive (AR) deficiencies [interferon regulatory factor 7 (IRF7) and IFNAR1] and autosomal-dominant deficiencies (AD) [toll-like receptor 3 (TLR3), UNC93B1, TICAM1, TBK1, IRF3, IRF7, IFNAR1, and IFNAR2].