Following viral infection, the helicase domain of RIG-I or melanoma differentiation-associated protein 5 (MDA5) of RLR family binds to dsRNA and the recruitment domain binds to mitochondrial antiviral signal protein, which is also known as IPS1 (Kell and Gale, 2015; Esser-Nobis et al., 2020). This evidence concerns the gene IFIH1 and viral infectious disease.