The four clusters that resulted from Cohort-1 were as follows (Figure 3A): Cluster 1 (denoted as metabolic healthy obesity [MHO]): 388 (44%) patients characterized by relatively healthy-metabolic statues, with normal glucose (median glucose AUC: 928 vs. 886 mmol/l·min in normal-weight), slight compensated insulin secretion (median insulin AUC: 13775 vs. 7252 mU/l·min in normal-weight), and mild increased UA (median: 363 vs. 267 μmol/l in normal-weight). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.