In the present study, the respective median changes from baseline in UFC and ACTH were 4.0 nmol/d (1.4 μg/24 h) and 3.7 pmol/L (16.8 pg/mL) in the ACTH-dependent CS group and 7.0 nmol/d (2.6 μg/24 h) and 0.2 pmol/L (0.9 pg/mL) in the adrenal group. This evidence concerns the gene POMC and Cowden syndrome 1.