In a series of 8 T2D patients, 5 of whom were insulin-requiring, data from this approach were analyzed either using the unmodified Minimal Model of Bergman (BMM), or a modified model (MMD) with an additional element (in this case DT18 in SAAM terminology) representing a time delay in the transfer of insulin into the remote insulin compartment (X). Here, INS is linked to type 2 diabetes mellitus.