Although this method successfully accommodated data from healthy subjects and a variety of pathological states in fitting the gMM, we found it could not fit data from many patients with Type 1 diabetes (T1D) because: there was insufficient insulin input into the model as commented by Pacini and Bergman (4); and, insulin antibodies in many T1D interfered with the measurement of plasma insulin. Here, INS is linked to type 1 diabetes mellitus.