To screen the APC members that might be involved in the regulation of fecundity in BPHs, the temporal and spatial expression patterns of all BPH APC members were comprehensively evaluated, and the APC member of NlAPC09 was selected, which reached its highest gene expression levels in both adult insects and ovaries compared with other growth stages and tissues (Figures 5A,B). The gene discussed is APC; the disease is benign prostatic hyperplasia.