RAF1 and Hepatic fibrosis: It has been reported that the auto-phosphorylated PDGFR and downstream activation of Ras, RAF pro-oncogene serine/threonine protein kinase (RAF-1), mitogen-activated protein kinase (MEK) and extracellular signal-regulated protein kinase (ERK) signaling pathways facilitate the progression of hepatic fibrosis (Ying et al., 2017).