PDGFRB and Hepatic fibrosis: Similar antifibrotic effects can also be achieved through direct administration of PDGF-BB specific neutralizing antibody (MOR8457) (Yoshida et al., 2014; Kuai et al., 2015) or soluble dominant negative PDGFRβ (Borkham-Kamphorst et al., 2004), as demonstrated in mice model of hepatic fibrosis.