Hao et al. (2012) demonstrated that PDGF-B kinoid immunogen, a kind of PDGF-B-derived epitope-carrier protein heterocomplexes, would elicit the production of neutralizing anti-PDGF-B autoantibodies responsible for the suppression of proliferation and activation of the hepatic stellate cells (HSCs), which would ultimately inhibit liver fibrosis. The gene discussed is PDGFB; the disease is Hepatic fibrosis.