Regarding lipid homeostasis and fibrosis related genes including PPARα, PPARα, and TGFβ1, Collagen 1A1, PDGFα genes in ALD patients, contrary to NAFLD patients show different patterns especially increase of DNA methylation at the site of TGFβ1 exon was upregulated in CpG2, but reverse manner of Collagen 1A1 gene (Zeybel et al., 2015; Figure 1B). Here, PPARA is linked to metabolic dysfunction-associated steatotic liver disease.