This finding suggests that we can use mTOR as a target for obesity treatment, and by blocking the activity of mTOR, we can change the quality and function of mitochondria, thus promoting the conversion of WAT to BAT and increasing energy expenditure, which may be important for the prevention and treatment of obesity (Xiang et al., 2015; Dai et al., 2018; Shen et al., 2018). The gene discussed is MTOR; the disease is obesity due to melanocortin 4 receptor deficiency.